Introducing Varvimax™
A Medical Food Solution to Chronic Pain & Inflammation
Varvimax™ was formulated to address the underlying dietary and amino acid deficiencies that are commonly associated with chronic pain and inflammatory disorders. Varvimax™ is designed with a specific formulation of supplements, vitamins, bioflavonoids, and amino acids that work in junction with one another to address the dietary requirements of the metabolic disorders involved in chronic pain, inflammatory conditions, and fatigue.
Studies have shown that these ingredients have been effective in reducing pain and inflammation, as well as improving joint function in patients with arthritis, fibromyalgia, and other inflammatory conditions.
Varvimax™:
A Natural Solution to Chronic Pain
Varvimax™ contains all-natural ingredients that have been clinically proven to target chronic pain & inflammation at its root to truly provide long-term relief.
This unique & revolutionary blend of amino acids, supplements, bioflavonoids, and vitamins also provides essential nutrients to support overall health.
Clinical Support for Varvimax
Please find attached here below a peer-reviewed article entitled “The Role of VARVIMAX™ In the Treatment of Chronic Inflammation and Pain in Arthritis and Fibromyalgia” by Dr. Imdad Ullah, published in the Journal of Advances in Medicine and Medical Research, June 15, 2023.
Ingredients
Varvimax™ contains the following ingredients:
Curcumin, which is the main active ingredient of Tumeric, has powerful anti-inflammatory properties that promote soothing comfort in muscles and joints by blocking the COX-2 enzymes responsible for inflammation and pain. In addition, curcumin also boosts the activity of your body’s antioxidant enzymes. In that way, curcumin delivers a one-two punch against free radicals, blocking them directly and then stimulating antioxidant defenses.
L-Arginine is an amino acid that can improve blood flow and clear out inflammation in the body. The antioxidant supplementation of L-Arginine restores the balance between reactive oxygen species and antioxidants, thereby protecting tissues from the harmful effects of oxidative stress.
It’s no secret that matcha green tea leaf powder has amazing antioxidative properties. Studies have shown that when matcha green tea is used in addition to a balanced diet, it can improve the overall antioxidative status and protect against oxidative damage within the body.
Choline has been shown to reduce inflammation in the body. A clinical study published in the American Journal of Clinical Nutrition showed that study participants who had higher levels of choline had lower levels of inflammation markers, such as C-reactive protein or CRP, in their blood.
Japanese Knotweed (Polygonum cuspidatum Extract (root) 98% resveratrol) is a rich source of antioxidant agents that also provide anti-inflammatory potential. It helps prevent oxidative stress and improves cellular integrity. In the case of inflammation, studies reported that grape seed extract suppresses the release and expression of pro-inflammatory cytokines (IL-6, IL-8, IL-1β and tumor necrosis factor-alpha, etc.) responsible for inflammation progression or development [65]. Moreover, it modulates gut microbiota, improves gut immune response, and supports optimal gut microbiota. These gut health benefits may help the management of inflammatory conditions in the gastrointestinal tract. Additionally, grape seed extract supplementation increases the expression of anti-inflammatory cytokines such as interleukin-10 and transforming growth factor-beta-1, helping suppress inflammation.
Panax ginseng, well known for its medicinal properties, regulates each type of immune cell including, macrophages, natural killer cells, dendritic cells, T cells, and B cells. Ginseng can alleviate pathological symptoms and prevent potential diseases thanks to its anti-inflammatory, antioxidant, and homeostatic properties, as well as have other positive effects on your biological metabolism.
GABA (Gamma-Aminobutyric Acid) is an inhibitory neurotransmitter in the nervous system that suppresses the sensation of pain and anxiety. It is the most prevalent inhibitory neurotransmitter with high concentrations in the brain and spinal cord and is present in 60-70% of all synapses in the central nervous system. GABA plays an important role in sensitivity for neuronal firing, mood, cognition, pain, sleep, and movement disorders.
Boswellia and its active ingredients, such as boswellic acid, have a good anti-inflammatory effect on the body. One of these acids, boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. Modern medicine and pharmacology strongly point out to its use as an antiarthritic, anti-inflammatory, anti-hyperlipidemic (controls blood lipids), anti-atherosclerotic (anticoronary plaque), analgesic (pain-reliever) and it being hepatoprotective (protects the liver).
5-Hydroxytryptophan, or 5-HTP for short, suppresses inflammation and arthritic pain by decreasing the production of pro-inflammatory mediators. It’s an amino acid, meaning it builds muscles, causes chemical reactions in the body, transports nutrients, prevents illness, and carries out other functions. We chose to formulate Varvimax™ using 5-HTP because it is the amino acid that metabolizes into serotonin, a neurotransmitter that controls mood and pain.
Glutamine, an amino acid, is an abundant constituent of proteins. It is the only amino acid capable of readily crossing the blood/brain barrier and, with glutamic acid, is thought to account for about 80 percent of the amino nitrogen of brain tissue.
Serine is an amino acid that plays a crucial role in the body’s metabolic processes. A study published in the journal Cell Metabolism found that serine can be used to control inflammation by modulating levels of a protein known as IL-1ß. The study showed that when macrophage cells were deprived of serine, their glutathione levels decreased, which in turn decreased levels of IL-1ß. This suggests that serine can control inflammation by regulating the production of IL-1ß.
Piperine is added to enhance the bioavailability of curcumin and other ingredients for optimal therapeutic properties against chronic pain and inflammation. Studies also showed the anti-inflammatory effect of piperine isolated from black pepper through inhibiting enzymes (COX-2) and inflammatory cytokines (TNF-α and Interleukins-6) involved in the inflammatory cascade.
Vitamin B6, also known as pyridoxine, belongs to the vitamin B family and is important for metabolism, immune response, neurotransmission, and other physiological functions. Studies on vitamin B6 revealed significant anti-inflammatory and analgesic potential in the management of various chronic medical conditions. It effectively inhibits the pro-inflammatory cytokines (TNF-α, interleukins) and also suppresses the enzymatic activity of inflammatory enzymes such as COX-2 and iNOs responsible for inflammatory cascade.
Astaxanthin has been shown to reduce inflammation by acting on reactive oxygen species to reduce proteins that can cause inflammatory diseases like celiac disease, rheumatoid arthritis, heart disease, and diabetes. Astaxanthin also supports joint and muscle health, promotes heart health, supports cognitive function, and improves immune function.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is found in high concentrations in the brain and retina. DHA is known to have several health benefits, including reducing inflammation and pain. A study published in the journal Nutrients found that DHA can help reduce inflammation by modulating the production of cytokines, which are proteins that play a key role in the immune response.
Another study published in the same journal found that DHA can help reduce the symptoms of rheumatoid arthritis, a chronic inflammatory disorder that causes joint pain and swelling. DHA has also been shown to reduce the risk of heart disease by lowering triglyceride levels and improving cholesterol profiles.
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that is found in cold-water fish and seafood. EPA has been shown to reduce inflammation by modulating the production of cytokines, which are proteins that play a key role in the immune response. A study published in the Proceedings of the National Academy of Sciences found that EPA can reduce both neuropathic and inflammatory pain by inhibiting an important signaling molecule called vesicular nucleotide transporter.
Another study published in the journal Nutrients found that higher intakes of omega-3 PUFAs, especially EPA and docosahexaenoic acid (DHA), are associated with a lower incidence of chronic diseases characterized by elevated inflammation, including cardiovascular diseases.
The composition of Lanfam VARVIMAX™ targets inflammation and pro-inflammatory proteins. VARVIMAX™ is made without gluten, dairy, soy, corn, and nuts.
Lanfam products are formulated with organic ingredients, and are fortified with evidence-based protein-free phytochemical extracts to support the body’s ability to fight inflammation and oxidation.
Lanfam products are manufactured in the USA and are ideally suited for patients with compromised immune systems caused by inflammatory arthritis.
VARVIMAX™ is a medical food that must be used under medical supervision, including as directed by a physician or medical professional.
VARVIMAX™ is available by prescription through a durable medical equipment (DME) company.
Varvimax Indications
VARVIMAX™ targets inflammatory arthritis. Inflammatory arthritis refers to any type of arthritis where your body's immune system mistakenly attacks healthy tissue, causing chronic inflammation. The types of inflammatory arthritis that Varvimax is most effective is:
RA is one of the most common forms of inflammatory arthritis. It typically affects joints in the hands, wrists, and knees.
PsA is a chronic (long-lasting) form of arthritis that typically occurs in people with psoriasis—an autoimmune condition that speeds up the growth of skin cells. Roughly 30% of people with psoriasis develop PsA.
There has been an evolution of thought about whether inflammation is what causes osteoarthritis. And research is now showing that it is thought to be an inflammatory disease. Inflammation (swelling, pain, and warmth) of a synovial membrane, which is a layer of connective tissue that lines a joint, such as the hip, knee, ankle, or shoulder. Synovitis is caused by some types of arthritis and other diseases.
AS is a chronic form of arthritis that causes inflammation of the spine and sacroiliac joints (where the spine connects with the pelvis). It can also affect the hips and knees.
SLE is the most common type of lupus—up to 70% of people with lupus have it. SLE causes inflammation in multiple organs and systems in the body. It can affect the heart, lungs, kidneys, and brain. Often referred to as simply "lupus."
Gout, a painful and potentially debilitating form of inflammatory arthritis, develops when tiny, needle-shaped crystals of uric acid (a biological waste product) accumulate in the joints.
The role of inflammation in fibromyalgia has been the topic of debate for decades. Fibromyalgia is frequently referred to as an arthritis-related condition. In recent years, multiple studies have revealed several markers of inflammation in people with fibromyalgia, including high levels of C-reactive protein and pro-inflammatory cytokines.